“I’m ready for my close-up …”
Beginning with the descendants of John and Elizabeth Howland (and thus also of John and Joan Tilley), we can highlight the film director Cecil B de Mille, who was a descendant of the Howlands on (at least) three separate lines. Although I don’t know whether CB ever directed him, movie actor cousins would have included Humphrey Bogart.
More recently we can count Christopher Lloyd (also a Warren and Chilton descendant), Tuesday Weld (wife of Dudley Moore and Pinchas Zukerman; she is also a Warren cousin), Cornelius Crane (“Chevy”) Chase (also a Brewster descendant), John Lithgow (also a Bradford and Billington descendant), Glen Close, Ted Danson (Edward Bridge Danson III -- which sounds much more Mayflower-y -- he is also a Brewster descendant), William Macy, the Baldwin brothers (Alec, Daniel, Billy and Stephen) and Hailey Baldwin (Mrs. Justin Bieber!): these Baldwins are also Bradford descendants, and Matt Bomer
Movie actor descendants of John and Priscilla Alden include Orson Welles, Shirley Temple, Marilyn Monroe (nee Norma Jean Baker), Raquel Welch (also a Doty and Eaton descendant), Jodie Foster, James Brolin (and thus Josh Brolin, as well), and Zac Efron.
The surprise addition to the Alden cousins is Benedict Cumberbatch. While many of these have multiple Mayflower lines, for quite a few it is apparent that all one needs is one single line to become a Mayflower descendant!